In the spring semester of 1994 a small group of men petitioned to establish a colony of Phi Mu Alpha Sinfonia National Fraternity on the campus of Western Carolina University. Their petition was granted and the North Carolina Beta Colony began their work to start a new chapter of Phi Mu Alpha. In January of 1995, the colony moved into phase II of colonization. With the help of the Rho Tau chapter of Appalachian State University, the fourteen members of the colony began their probationary membership period.

On April 29, 1995, on the campus of Appalachian State University, Omicron Epsilon was presented with a charter by national president Dr. Richard A. Crosby and Province 20 governor John Doherty. Those fourteen men became known as the Alpha class.

Since that time the chapter has worked hard to become a leader in the state of North Carolina. Having produced 2 CPR's, 4 ACPR's, the first province historian, a province webmaster, and over 100 collegiate brothers in its short history, the chapter has proven itself a valuable addition to the national fraternity. The chapter continues to provide service to the department of music and the university community, through special programs, recitals, volunteer work, and musical events.